{"id":330,"date":"2023-06-23T13:16:00","date_gmt":"2023-06-23T13:16:00","guid":{"rendered":"https:\/\/gregoryquirk.org\/wordpress\/?p=330"},"modified":"2025-06-23T13:17:09","modified_gmt":"2025-06-23T13:17:09","slug":"a-novel-insular-orbital-prelimbic-circuit-that-prevents-persistent-avoidance-in-a-rodent-model-of-compulsive-behavior","status":"publish","type":"post","link":"https:\/\/gregoryquirk.org\/index.php\/2023\/06\/23\/a-novel-insular-orbital-prelimbic-circuit-that-prevents-persistent-avoidance-in-a-rodent-model-of-compulsive-behavior\/","title":{"rendered":"A Novel Insular\/Orbital-Prelimbic Circuit That Prevents Persistent Avoidance in a Rodent Model of Compulsive Behavior"},"content":{"rendered":"\n

Biological Psychiatry Volume 93,\u00a0Issue 11<\/a> p1000-1009
June 01, 2023<\/p>\n\n\n\n

Freddyson J Mart\u00ednez-Rivera<\/a>\u00a0<\/sup>,\u00a0Jos\u00e9 P\u00e9rez-Torres<\/a>\u00a0<\/sup>,\u00a0Coraly D Vel\u00e1zquez-D\u00edaz<\/a>\u00a0<\/sup>,\u00a0Marcos J S\u00e1nchez-Navarro<\/a>\u00a0<\/sup>,\u00a0Carlos I Huertas-P\u00e9rez<\/a>\u00a0<\/sup>,\u00a0Maria M Diehl<\/a>\u00a0<\/sup>,\u00a0Mary L Phillips<\/a>\u00a0<\/sup>,\u00a0Suzanne N Haber<\/a>\u00a0<\/sup>,\u00a0Gregory J Quirk<\/a>\u00a0<\/sup><\/p>\n\n\n\n

Abstract<\/h2>\n\n\n\n

Background: <\/strong>A common symptom of obsessive-compulsive disorder is the persistent avoidance of cues incorrectly associated with negative outcomes. This maladaptation becomes increasingly evident as subjects fail to respond to extinction-based treatments such as exposure-with-response prevention therapy. While previous studies have highlighted the role of the insular-orbital cortex in fine-tuning avoidance-based decisions, little is known about the projections from this area that might modulate compulsive-like avoidance.<\/p>\n\n\n\n

Methods: <\/strong>Here, we used anatomical tract-tracing, single-unit recording, and optogenetics to characterize the projections from the insular-orbital cortex. To model exposure-with-response prevention and persistent avoidance in rats, we used the platform-mediated avoidance task followed by extinction-with-response prevention training.<\/p>\n\n\n\n

Results: <\/strong>Using tract-tracing and unit recording, we found that projections from the agranular insular\/lateral orbital (AI\/LO) cortex to the prefrontal cortex predominantly target the rostral portion of the prelimbic (rPL) cortex and excite rPL neurons. Photoinhibiting this projection induced persistent avoidance after extinction-with-response prevention training, an effect that was still present 1 week later. Consistent with this, photoexcitation of this projection prevented persistent avoidance in overtrained rats. This projection to rPL appears to be key for AI\/LO’s effects, considering that there was no effect of photoinhibiting AI\/LO projections to the ventral striatum or basolateral amygdala.<\/p>\n\n\n\n

Conclusions: <\/strong>Our findings suggest that projections from the AI\/LO to the rPL decreases the likelihood of avoidance behavior following extinction. In humans, this connectivity may share some homology of projections from lateral prefrontal cortices (i.e., ventrolateral prefrontal cortex, orbitofrontal cortex, and insula) to other prefrontal areas and the anterior cingulate cortex, suggesting that reduced activity in these pathways may contribute to obsessive-compulsive disorder.<\/p>\n\n\n\n

Keywords: <\/strong>Avoidance; Extinction; Insula; OCD; Orbitofrontal cortex; Prefrontal cortex.<\/p>\n\n\n\n

Copyright \u00a9 2022 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.<\/p>\n\n\n\n

Reference:<\/strong> Biological Psychiatry<\/a><\/p>\n\n\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

Biological Psychiatry Volume 93,\u00a0Issue 11 p1000-1009June 01, 2023 Freddyson J Mart\u00ednez-Rivera\u00a0,\u00a0Jos\u00e9 P\u00e9rez-Torres\u00a0,\u00a0Coraly D Vel\u00e1zquez-D\u00edaz\u00a0,\u00a0Marcos J S\u00e1nchez-Navarro\u00a0,\u00a0Carlos I Huertas-P\u00e9rez\u00a0,\u00a0Maria M Diehl\u00a0,\u00a0Mary L Phillips\u00a0,\u00a0Suzanne N Haber\u00a0,\u00a0Gregory J Quirk\u00a0 Abstract Background: A common symptom of obsessive-compulsive disorder is the persistent avoidance of cues incorrectly associated with negative outcomes. This maladaptation becomes increasingly evident as subjects fail to respond to […]<\/p>\n","protected":false},"author":1,"featured_media":333,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"saved_in_kubio":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-330","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized"],"yoast_head":"\nA Novel Insular\/Orbital-Prelimbic Circuit That Prevents Persistent Avoidance in a Rodent Model of Compulsive Behavior - Gregory J. Quirk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/gregoryquirk.org\/index.php\/2023\/06\/23\/a-novel-insular-orbital-prelimbic-circuit-that-prevents-persistent-avoidance-in-a-rodent-model-of-compulsive-behavior\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"A Novel Insular\/Orbital-Prelimbic Circuit That Prevents Persistent Avoidance in a Rodent Model of Compulsive Behavior - Gregory J. Quirk\" \/>\n<meta property=\"og:description\" content=\"Biological Psychiatry Volume 93,\u00a0Issue 11 p1000-1009June 01, 2023 Freddyson J Mart\u00ednez-Rivera\u00a0,\u00a0Jos\u00e9 P\u00e9rez-Torres\u00a0,\u00a0Coraly D Vel\u00e1zquez-D\u00edaz\u00a0,\u00a0Marcos J S\u00e1nchez-Navarro\u00a0,\u00a0Carlos I Huertas-P\u00e9rez\u00a0,\u00a0Maria M Diehl\u00a0,\u00a0Mary L Phillips\u00a0,\u00a0Suzanne N Haber\u00a0,\u00a0Gregory J Quirk\u00a0 Abstract Background: A common symptom of obsessive-compulsive disorder is the persistent avoidance of cues incorrectly associated with negative outcomes. This maladaptation becomes increasingly evident as subjects fail to respond to […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/gregoryquirk.org\/index.php\/2023\/06\/23\/a-novel-insular-orbital-prelimbic-circuit-that-prevents-persistent-avoidance-in-a-rodent-model-of-compulsive-behavior\/\" \/>\n<meta property=\"og:site_name\" content=\"Gregory J. Quirk\" \/>\n<meta property=\"article:published_time\" content=\"2023-06-23T13:16:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-06-23T13:17:09+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/gregoryquirk.org\/wordpress\/wp-content\/uploads\/2025\/06\/Biological-Psychiatry-2023.png\" \/>\n\t<meta property=\"og:image:width\" content=\"452\" \/>\n\t<meta property=\"og:image:height\" content=\"602\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/gregoryquirk.org\/index.php\/2023\/06\/23\/a-novel-insular-orbital-prelimbic-circuit-that-prevents-persistent-avoidance-in-a-rodent-model-of-compulsive-behavior\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/gregoryquirk.org\/index.php\/2023\/06\/23\/a-novel-insular-orbital-prelimbic-circuit-that-prevents-persistent-avoidance-in-a-rodent-model-of-compulsive-behavior\/\"},\"author\":{\"name\":\"admin\",\"@id\":\"https:\/\/gregoryquirk.org\/#\/schema\/person\/ce104fefc235bcf5a060945e15ad185b\"},\"headline\":\"A Novel Insular\/Orbital-Prelimbic Circuit That Prevents Persistent Avoidance in a Rodent Model of Compulsive Behavior\",\"datePublished\":\"2023-06-23T13:16:00+00:00\",\"dateModified\":\"2025-06-23T13:17:09+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/gregoryquirk.org\/index.php\/2023\/06\/23\/a-novel-insular-orbital-prelimbic-circuit-that-prevents-persistent-avoidance-in-a-rodent-model-of-compulsive-behavior\/\"},\"wordCount\":352,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/gregoryquirk.org\/#\/schema\/person\/b688edbc0d72ac65d6d643cb49330b6a\"},\"image\":{\"@id\":\"https:\/\/gregoryquirk.org\/index.php\/2023\/06\/23\/a-novel-insular-orbital-prelimbic-circuit-that-prevents-persistent-avoidance-in-a-rodent-model-of-compulsive-behavior\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/gregoryquirk.org\/wordpress\/wp-content\/uploads\/2025\/06\/Biological-Psychiatry-2023.png\",\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/gregoryquirk.org\/index.php\/2023\/06\/23\/a-novel-insular-orbital-prelimbic-circuit-that-prevents-persistent-avoidance-in-a-rodent-model-of-compulsive-behavior\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/gregoryquirk.org\/index.php\/2023\/06\/23\/a-novel-insular-orbital-prelimbic-circuit-that-prevents-persistent-avoidance-in-a-rodent-model-of-compulsive-behavior\/\",\"url\":\"https:\/\/gregoryquirk.org\/index.php\/2023\/06\/23\/a-novel-insular-orbital-prelimbic-circuit-that-prevents-persistent-avoidance-in-a-rodent-model-of-compulsive-behavior\/\",\"name\":\"A Novel Insular\/Orbital-Prelimbic Circuit That Prevents Persistent Avoidance in a Rodent Model of Compulsive Behavior - Gregory J. Quirk\",\"isPartOf\":{\"@id\":\"https:\/\/gregoryquirk.org\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/gregoryquirk.org\/index.php\/2023\/06\/23\/a-novel-insular-orbital-prelimbic-circuit-that-prevents-persistent-avoidance-in-a-rodent-model-of-compulsive-behavior\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/gregoryquirk.org\/index.php\/2023\/06\/23\/a-novel-insular-orbital-prelimbic-circuit-that-prevents-persistent-avoidance-in-a-rodent-model-of-compulsive-behavior\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/gregoryquirk.org\/wordpress\/wp-content\/uploads\/2025\/06\/Biological-Psychiatry-2023.png\",\"datePublished\":\"2023-06-23T13:16:00+00:00\",\"dateModified\":\"2025-06-23T13:17:09+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/gregoryquirk.org\/index.php\/2023\/06\/23\/a-novel-insular-orbital-prelimbic-circuit-that-prevents-persistent-avoidance-in-a-rodent-model-of-compulsive-behavior\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/gregoryquirk.org\/index.php\/2023\/06\/23\/a-novel-insular-orbital-prelimbic-circuit-that-prevents-persistent-avoidance-in-a-rodent-model-of-compulsive-behavior\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/gregoryquirk.org\/index.php\/2023\/06\/23\/a-novel-insular-orbital-prelimbic-circuit-that-prevents-persistent-avoidance-in-a-rodent-model-of-compulsive-behavior\/#primaryimage\",\"url\":\"https:\/\/gregoryquirk.org\/wordpress\/wp-content\/uploads\/2025\/06\/Biological-Psychiatry-2023.png\",\"contentUrl\":\"https:\/\/gregoryquirk.org\/wordpress\/wp-content\/uploads\/2025\/06\/Biological-Psychiatry-2023.png\",\"width\":452,\"height\":602},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/gregoryquirk.org\/index.php\/2023\/06\/23\/a-novel-insular-orbital-prelimbic-circuit-that-prevents-persistent-avoidance-in-a-rodent-model-of-compulsive-behavior\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/gregoryquirk.org\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"A Novel Insular\/Orbital-Prelimbic Circuit That Prevents Persistent Avoidance in a Rodent Model of Compulsive Behavior\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/gregoryquirk.org\/#website\",\"url\":\"https:\/\/gregoryquirk.org\/\",\"name\":\"Gregory J. Quirk\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\/\/gregoryquirk.org\/#\/schema\/person\/b688edbc0d72ac65d6d643cb49330b6a\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/gregoryquirk.org\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":[\"Person\",\"Organization\"],\"@id\":\"https:\/\/gregoryquirk.org\/#\/schema\/person\/b688edbc0d72ac65d6d643cb49330b6a\",\"name\":\"Gregory Quirk\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/gregoryquirk.org\/wordpress\/wp-content\/uploads\/2025\/11\/image-1.jpg\",\"url\":\"https:\/\/gregoryquirk.org\/wordpress\/wp-content\/uploads\/2025\/11\/image-1.jpg\",\"contentUrl\":\"https:\/\/gregoryquirk.org\/wordpress\/wp-content\/uploads\/2025\/11\/image-1.jpg\",\"width\":873,\"height\":720,\"caption\":\"Gregory Quirk\"},\"logo\":{\"@id\":\"https:\/\/gregoryquirk.org\/wordpress\/wp-content\/uploads\/2025\/11\/image-1.jpg\"},\"sameAs\":[\"http:\/\/gregoryquirk.org\"]},{\"@type\":\"Person\",\"@id\":\"https:\/\/gregoryquirk.org\/#\/schema\/person\/ce104fefc235bcf5a060945e15ad185b\",\"name\":\"admin\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/secure.gravatar.com\/avatar\/cf6a846f1f868d2c3ee7ddd1f1d8324695fe9ce465966078249ef04ac3a2422d?s=96&d=mm&r=g\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/cf6a846f1f868d2c3ee7ddd1f1d8324695fe9ce465966078249ef04ac3a2422d?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/cf6a846f1f868d2c3ee7ddd1f1d8324695fe9ce465966078249ef04ac3a2422d?s=96&d=mm&r=g\",\"caption\":\"admin\"},\"sameAs\":[\"https:\/\/gregoryquirk.org\/wordpress\"],\"url\":\"https:\/\/gregoryquirk.org\/index.php\/author\/admin_greg\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"A Novel Insular\/Orbital-Prelimbic Circuit That Prevents Persistent Avoidance in a Rodent Model of Compulsive Behavior - Gregory J. Quirk","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/gregoryquirk.org\/index.php\/2023\/06\/23\/a-novel-insular-orbital-prelimbic-circuit-that-prevents-persistent-avoidance-in-a-rodent-model-of-compulsive-behavior\/","og_locale":"en_US","og_type":"article","og_title":"A Novel Insular\/Orbital-Prelimbic Circuit That Prevents Persistent Avoidance in a Rodent Model of Compulsive Behavior - Gregory J. Quirk","og_description":"Biological Psychiatry Volume 93,\u00a0Issue 11 p1000-1009June 01, 2023 Freddyson J Mart\u00ednez-Rivera\u00a0,\u00a0Jos\u00e9 P\u00e9rez-Torres\u00a0,\u00a0Coraly D Vel\u00e1zquez-D\u00edaz\u00a0,\u00a0Marcos J S\u00e1nchez-Navarro\u00a0,\u00a0Carlos I Huertas-P\u00e9rez\u00a0,\u00a0Maria M Diehl\u00a0,\u00a0Mary L Phillips\u00a0,\u00a0Suzanne N Haber\u00a0,\u00a0Gregory J Quirk\u00a0 Abstract Background: A common symptom of obsessive-compulsive disorder is the persistent avoidance of cues incorrectly associated with negative outcomes. This maladaptation becomes increasingly evident as subjects fail to respond to […]","og_url":"https:\/\/gregoryquirk.org\/index.php\/2023\/06\/23\/a-novel-insular-orbital-prelimbic-circuit-that-prevents-persistent-avoidance-in-a-rodent-model-of-compulsive-behavior\/","og_site_name":"Gregory J. Quirk","article_published_time":"2023-06-23T13:16:00+00:00","article_modified_time":"2025-06-23T13:17:09+00:00","og_image":[{"width":452,"height":602,"url":"https:\/\/gregoryquirk.org\/wordpress\/wp-content\/uploads\/2025\/06\/Biological-Psychiatry-2023.png","type":"image\/png"}],"author":"admin","twitter_card":"summary_large_image","twitter_misc":{"Written by":"admin","Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/gregoryquirk.org\/index.php\/2023\/06\/23\/a-novel-insular-orbital-prelimbic-circuit-that-prevents-persistent-avoidance-in-a-rodent-model-of-compulsive-behavior\/#article","isPartOf":{"@id":"https:\/\/gregoryquirk.org\/index.php\/2023\/06\/23\/a-novel-insular-orbital-prelimbic-circuit-that-prevents-persistent-avoidance-in-a-rodent-model-of-compulsive-behavior\/"},"author":{"name":"admin","@id":"https:\/\/gregoryquirk.org\/#\/schema\/person\/ce104fefc235bcf5a060945e15ad185b"},"headline":"A Novel Insular\/Orbital-Prelimbic Circuit That Prevents Persistent Avoidance in a Rodent Model of Compulsive Behavior","datePublished":"2023-06-23T13:16:00+00:00","dateModified":"2025-06-23T13:17:09+00:00","mainEntityOfPage":{"@id":"https:\/\/gregoryquirk.org\/index.php\/2023\/06\/23\/a-novel-insular-orbital-prelimbic-circuit-that-prevents-persistent-avoidance-in-a-rodent-model-of-compulsive-behavior\/"},"wordCount":352,"commentCount":0,"publisher":{"@id":"https:\/\/gregoryquirk.org\/#\/schema\/person\/b688edbc0d72ac65d6d643cb49330b6a"},"image":{"@id":"https:\/\/gregoryquirk.org\/index.php\/2023\/06\/23\/a-novel-insular-orbital-prelimbic-circuit-that-prevents-persistent-avoidance-in-a-rodent-model-of-compulsive-behavior\/#primaryimage"},"thumbnailUrl":"https:\/\/gregoryquirk.org\/wordpress\/wp-content\/uploads\/2025\/06\/Biological-Psychiatry-2023.png","inLanguage":"en-US","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/gregoryquirk.org\/index.php\/2023\/06\/23\/a-novel-insular-orbital-prelimbic-circuit-that-prevents-persistent-avoidance-in-a-rodent-model-of-compulsive-behavior\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/gregoryquirk.org\/index.php\/2023\/06\/23\/a-novel-insular-orbital-prelimbic-circuit-that-prevents-persistent-avoidance-in-a-rodent-model-of-compulsive-behavior\/","url":"https:\/\/gregoryquirk.org\/index.php\/2023\/06\/23\/a-novel-insular-orbital-prelimbic-circuit-that-prevents-persistent-avoidance-in-a-rodent-model-of-compulsive-behavior\/","name":"A Novel Insular\/Orbital-Prelimbic Circuit That Prevents Persistent Avoidance in a Rodent Model of Compulsive Behavior - Gregory J. Quirk","isPartOf":{"@id":"https:\/\/gregoryquirk.org\/#website"},"primaryImageOfPage":{"@id":"https:\/\/gregoryquirk.org\/index.php\/2023\/06\/23\/a-novel-insular-orbital-prelimbic-circuit-that-prevents-persistent-avoidance-in-a-rodent-model-of-compulsive-behavior\/#primaryimage"},"image":{"@id":"https:\/\/gregoryquirk.org\/index.php\/2023\/06\/23\/a-novel-insular-orbital-prelimbic-circuit-that-prevents-persistent-avoidance-in-a-rodent-model-of-compulsive-behavior\/#primaryimage"},"thumbnailUrl":"https:\/\/gregoryquirk.org\/wordpress\/wp-content\/uploads\/2025\/06\/Biological-Psychiatry-2023.png","datePublished":"2023-06-23T13:16:00+00:00","dateModified":"2025-06-23T13:17:09+00:00","breadcrumb":{"@id":"https:\/\/gregoryquirk.org\/index.php\/2023\/06\/23\/a-novel-insular-orbital-prelimbic-circuit-that-prevents-persistent-avoidance-in-a-rodent-model-of-compulsive-behavior\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/gregoryquirk.org\/index.php\/2023\/06\/23\/a-novel-insular-orbital-prelimbic-circuit-that-prevents-persistent-avoidance-in-a-rodent-model-of-compulsive-behavior\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/gregoryquirk.org\/index.php\/2023\/06\/23\/a-novel-insular-orbital-prelimbic-circuit-that-prevents-persistent-avoidance-in-a-rodent-model-of-compulsive-behavior\/#primaryimage","url":"https:\/\/gregoryquirk.org\/wordpress\/wp-content\/uploads\/2025\/06\/Biological-Psychiatry-2023.png","contentUrl":"https:\/\/gregoryquirk.org\/wordpress\/wp-content\/uploads\/2025\/06\/Biological-Psychiatry-2023.png","width":452,"height":602},{"@type":"BreadcrumbList","@id":"https:\/\/gregoryquirk.org\/index.php\/2023\/06\/23\/a-novel-insular-orbital-prelimbic-circuit-that-prevents-persistent-avoidance-in-a-rodent-model-of-compulsive-behavior\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/gregoryquirk.org\/"},{"@type":"ListItem","position":2,"name":"A Novel Insular\/Orbital-Prelimbic Circuit That Prevents Persistent Avoidance in a Rodent Model of Compulsive Behavior"}]},{"@type":"WebSite","@id":"https:\/\/gregoryquirk.org\/#website","url":"https:\/\/gregoryquirk.org\/","name":"Gregory J. Quirk","description":"","publisher":{"@id":"https:\/\/gregoryquirk.org\/#\/schema\/person\/b688edbc0d72ac65d6d643cb49330b6a"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/gregoryquirk.org\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":["Person","Organization"],"@id":"https:\/\/gregoryquirk.org\/#\/schema\/person\/b688edbc0d72ac65d6d643cb49330b6a","name":"Gregory Quirk","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/gregoryquirk.org\/wordpress\/wp-content\/uploads\/2025\/11\/image-1.jpg","url":"https:\/\/gregoryquirk.org\/wordpress\/wp-content\/uploads\/2025\/11\/image-1.jpg","contentUrl":"https:\/\/gregoryquirk.org\/wordpress\/wp-content\/uploads\/2025\/11\/image-1.jpg","width":873,"height":720,"caption":"Gregory Quirk"},"logo":{"@id":"https:\/\/gregoryquirk.org\/wordpress\/wp-content\/uploads\/2025\/11\/image-1.jpg"},"sameAs":["http:\/\/gregoryquirk.org"]},{"@type":"Person","@id":"https:\/\/gregoryquirk.org\/#\/schema\/person\/ce104fefc235bcf5a060945e15ad185b","name":"admin","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/secure.gravatar.com\/avatar\/cf6a846f1f868d2c3ee7ddd1f1d8324695fe9ce465966078249ef04ac3a2422d?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/cf6a846f1f868d2c3ee7ddd1f1d8324695fe9ce465966078249ef04ac3a2422d?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/cf6a846f1f868d2c3ee7ddd1f1d8324695fe9ce465966078249ef04ac3a2422d?s=96&d=mm&r=g","caption":"admin"},"sameAs":["https:\/\/gregoryquirk.org\/wordpress"],"url":"https:\/\/gregoryquirk.org\/index.php\/author\/admin_greg\/"}]}},"_links":{"self":[{"href":"https:\/\/gregoryquirk.org\/index.php\/wp-json\/wp\/v2\/posts\/330","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/gregoryquirk.org\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/gregoryquirk.org\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/gregoryquirk.org\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/gregoryquirk.org\/index.php\/wp-json\/wp\/v2\/comments?post=330"}],"version-history":[{"count":1,"href":"https:\/\/gregoryquirk.org\/index.php\/wp-json\/wp\/v2\/posts\/330\/revisions"}],"predecessor-version":[{"id":334,"href":"https:\/\/gregoryquirk.org\/index.php\/wp-json\/wp\/v2\/posts\/330\/revisions\/334"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/gregoryquirk.org\/index.php\/wp-json\/wp\/v2\/media\/333"}],"wp:attachment":[{"href":"https:\/\/gregoryquirk.org\/index.php\/wp-json\/wp\/v2\/media?parent=330"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/gregoryquirk.org\/index.php\/wp-json\/wp\/v2\/categories?post=330"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/gregoryquirk.org\/index.php\/wp-json\/wp\/v2\/tags?post=330"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}