{"id":327,"date":"2024-07-23T13:07:00","date_gmt":"2024-07-23T13:07:00","guid":{"rendered":"https:\/\/gregoryquirk.org\/wordpress\/?p=327"},"modified":"2025-06-23T13:12:29","modified_gmt":"2025-06-23T13:12:29","slug":"specific-patterns-of-endogenous-functional-connectivity-are-associated-with-harm-avoidance-in-obsessive-compulsive-disorder","status":"publish","type":"post","link":"https:\/\/gregoryquirk.org\/index.php\/2024\/07\/23\/specific-patterns-of-endogenous-functional-connectivity-are-associated-with-harm-avoidance-in-obsessive-compulsive-disorder\/","title":{"rendered":"Specific Patterns of Endogenous Functional Connectivity Are Associated With Harm Avoidance in Obsessive-Compulsive Disorder"},"content":{"rendered":"\n

Biological Psychiatry Volume 96,\u00a0Issue 2<\/a>p137-146
July 15, 2024<\/p>\n\n\n\n

Merage Ghane<\/a>\u00a0<\/sup>,\u00a0Lucas Trambaiolli<\/a>\u00a0<\/sup>,\u00a0Michele A Bertocci<\/a>\u00a0<\/sup>,\u00a0Freddyson J Martinez-Rivera<\/a>\u00a0<\/sup>,\u00a0Henry W Chase<\/a>\u00a0<\/sup>,\u00a0Tyler Brady<\/a>\u00a0<\/sup>,\u00a0Alex Skeba<\/a>\u00a0<\/sup>,\u00a0Simona Graur<\/a>\u00a0<\/sup>,\u00a0Lisa Bonar<\/a>\u00a0<\/sup>,\u00a0Satish Iyengar<\/a>\u00a0<\/sup>,\u00a0Gregory J Quirk<\/a>\u00a0<\/sup>,\u00a0Steven A Rasmussen<\/a>\u00a0<\/sup>,\u00a0Suzanne N Haber<\/a>\u00a0<\/sup>,\u00a0Mary L Phillips<\/a>\u00a0<\/sup><\/p>\n\n\n\n

Abstract<\/h2>\n\n\n\n

Background: <\/strong>Individuals with obsessive-compulsive disorder (OCD) show persistent avoidance behaviors, often in the absence of actual threat. Quality-of-life costs and heterogeneity support the need for novel brain-behavior intervention targets. Informed by mechanistic and anatomical studies of persistent avoidance in rodents and nonhuman primates, our goal was to test whether connections within a hypothesized persistent avoidance-related network predicted OCD-related harm avoidance (HA), a trait measure of persistent avoidance. We hypothesized that 1) HA, not an OCD diagnosis, would be associated with altered endogenous connectivity in at least one connection in the network; 2) HA-specific findings would be robust to comorbid symptoms; and 3) reliable findings would replicate in a holdout testing subsample.<\/p>\n\n\n\n

Methods: <\/strong>Using resting-state functional connectivity magnetic resonance imaging, cross-validated elastic net for feature selection, and Poisson generalized linear models, we tested which connections significantly predicted HA in our training subsample (n = 73; 71.8% female; healthy control group n = 36, OCD group n = 37); robustness to comorbidities; and replicability in a testing subsample (n = 30; 56.7% female; healthy control group n = 15, OCD group n = 15).<\/p>\n\n\n\n

Results: <\/strong>Stronger inverse connectivity between the right dorsal anterior cingulate cortex and right basolateral amygdala and stronger positive connectivity between the right ventral anterior insula and left ventral striatum were associated with greater HA across groups. Network connections did not discriminate OCD diagnostic status or predict HA-correlated traits, suggesting sensitivity to trait HA. The dorsal anterior cingulate cortex-basolateral amygdala relationship was robust to controlling for comorbidities and medication in individuals with OCD and was also predictive of HA in our testing subsample.<\/p>\n\n\n\n

Conclusions: <\/strong>Stronger inverse dorsal anterior cingulate cortex-basolateral amygdala connectivity was robustly and reliably associated with HA across groups and in OCD. Results support the relevance of a cross-species persistent avoidance-related network to OCD, with implications for precision-based approaches and treatment.<\/p>\n\n\n\n

Keywords: <\/strong>BLA; Harm avoidance; OCD; Persistent avoidance; Resting-state functional connectivity; dACC.<\/p>\n\n\n\n

Copyright \u00a9 2024 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
Reference:<\/strong> Biological Psychiatry<\/a><\/p>\n\n\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

Biological Psychiatry Volume 96,\u00a0Issue 2p137-146July 15, 2024 Merage Ghane\u00a0,\u00a0Lucas Trambaiolli\u00a0,\u00a0Michele A Bertocci\u00a0,\u00a0Freddyson J Martinez-Rivera\u00a0,\u00a0Henry W Chase\u00a0,\u00a0Tyler Brady\u00a0,\u00a0Alex Skeba\u00a0,\u00a0Simona Graur\u00a0,\u00a0Lisa Bonar\u00a0,\u00a0Satish Iyengar\u00a0,\u00a0Gregory J Quirk\u00a0,\u00a0Steven A Rasmussen\u00a0,\u00a0Suzanne N Haber\u00a0,\u00a0Mary L Phillips\u00a0 Abstract Background: Individuals with obsessive-compulsive disorder (OCD) show persistent avoidance behaviors, often in the absence of actual threat. Quality-of-life costs and heterogeneity support the need for novel […]<\/p>\n","protected":false},"author":1,"featured_media":328,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"saved_in_kubio":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-327","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized"],"yoast_head":"\nSpecific Patterns of Endogenous Functional Connectivity Are Associated With Harm Avoidance in Obsessive-Compulsive Disorder - Gregory J. 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