{"id":1,"date":"2024-12-18T05:19:00","date_gmt":"2024-12-18T05:19:00","guid":{"rendered":"https:\/\/gregoryquirk.org\/wordpress\/?p=1"},"modified":"2025-06-23T13:39:21","modified_gmt":"2025-06-23T13:39:21","slug":"repeated-toluene-inhalation-in-male-and-female-adolescent-rats-induces-persistent-drug-preference-and-impairs-cognitive-and-social-behavior","status":"publish","type":"post","link":"https:\/\/gregoryquirk.org\/index.php\/2024\/12\/18\/repeated-toluene-inhalation-in-male-and-female-adolescent-rats-induces-persistent-drug-preference-and-impairs-cognitive-and-social-behavior\/","title":{"rendered":"Repeated toluene inhalation in male and female adolescent rats induces persistent drug preference and impairs cognitive and social behavior"},"content":{"rendered":"\n<p>Psychopharmacology <br>Volume\u00a0242,\u00a0pages 1335\u20131349, (2025)<br>18 December 2024<\/p>\n\n\n\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=%22Asis%20JLB%22%5BAuthor%5D\">Joannes Luke B Asis<\/a>&nbsp;,&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=%22Carampel%20AC%22%5BAuthor%5D\">Ajina C Carampel<\/a>,&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=%22Bacar%20JNB%22%5BAuthor%5D\">Jariel Naomi B Bacar<\/a>&nbsp;,&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=%22Munar%20JC%22%5BAuthor%5D\">Johanna C Munar<\/a>&nbsp;,&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=%22Gregorio%20CGC%22%5BAuthor%5D\">Cynthia Grace C Gregorio<\/a>&nbsp;,&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=%22Medina%20PMB%22%5BAuthor%5D\">Paul Mark B Medina<\/a>&nbsp;,&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=%22Dalmacio%20LMM%22%5BAuthor%5D\">Leslie Michelle M Dalmacio<\/a>&nbsp;,&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=%22Sevilleja%20JEAD%22%5BAuthor%5D\">Jesus Emmanuel A D Sevilleja<\/a>&nbsp;,&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=%22Quirk%20GJ%22%5BAuthor%5D\">Gregory J Quirk<\/a>&nbsp;,&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=%22Cena-Navarro%20R%22%5BAuthor%5D\">Rohani Cena-Navarro<\/a>&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Abstract<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">Rationale<\/h3>\n\n\n\n<p id=\"Par1\">Adolescent inhalant use is an understudied and undertreated disorder, particularly in females. Chronic exposure to inhalants, like toluene, can have long-lasting effects on behavior. However, most animal studies lack the incorporation of both sexes and do not focus on the abstinence period.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Objective<\/h3>\n\n\n\n<p id=\"Par2\">We assessed the behavioral effects during prolonged abstinence following repeated toluene inhalation in adolescent male and female rats.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Methods<\/h3>\n\n\n\n<p id=\"Par3\">We repeatedly exposed adolescent male and female Sprague Dawley rats to toluene vapor (1500 or 3000&nbsp;ppm) for 6&nbsp;days using the conditioned place preference (CPP) procedure. We tested drug-associated context preference, locomotion, anxiety-like behavior, object memory, social preference, and cognitive flexibility across 22&nbsp;days of abstinence.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Results<\/h3>\n\n\n\n<p id=\"Par4\">In females, 3000&nbsp;ppm toluene increased CPP on days 8 and 22 of abstinence but this effect did not reach significance in males. Instead, males showed a significant increase in locomotion on days 7 and 21. Toluene also impaired social novelty preference and reversal learning during long-term abstinence, but not anxiety-like behavior or object recognition memory.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Conclusions<\/h3>\n\n\n\n<p id=\"Par5\">Our rodent findings suggest that female inhalant users&nbsp;may&nbsp;show persistent drug preference during abstinence following chronic use. Furthermore, prolonged cognitive and social deficits should be addressed in treatment programs for adolescents.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Supplementary Information<\/h3>\n\n\n\n<p>The online version contains supplementary material available at 10.1007\/s00213-024-06731-5.<\/p>\n\n\n\n<p><strong>Keywords:<\/strong>&nbsp;Inhalants, Addiction, Abstinence, Conditioned place preference, Reversal, Social novelty<br><strong>Reference:<\/strong> <a href=\"https:\/\/link.springer.com\/article\/10.1007\/s00213-024-06731-5\" data-type=\"link\" data-id=\"https:\/\/link.springer.com\/article\/10.1007\/s00213-024-06731-5\" target=\"_blank\" rel=\"noreferrer noopener\">Springer Nature Link<\/a><\/p>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Psychopharmacology Volume\u00a0242,\u00a0pages 1335\u20131349, (2025)18 December 2024 Joannes Luke B Asis&nbsp;,&nbsp;Ajina C Carampel,&nbsp;Jariel Naomi B Bacar&nbsp;,&nbsp;Johanna C Munar&nbsp;,&nbsp;Cynthia Grace C Gregorio&nbsp;,&nbsp;Paul Mark B Medina&nbsp;,&nbsp;Leslie Michelle M Dalmacio&nbsp;,&nbsp;Jesus Emmanuel A D Sevilleja&nbsp;,&nbsp;Gregory J Quirk&nbsp;,&nbsp;Rohani Cena-Navarro&nbsp; Abstract Rationale Adolescent inhalant use is an understudied and undertreated disorder, particularly in females. Chronic exposure to inhalants, like toluene, can have [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":318,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"saved_in_kubio":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-1","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Repeated toluene inhalation in male and female adolescent rats induces persistent drug preference and impairs cognitive and social behavior - Gregory J. 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